| 1. Round | 20/08/2017 | AO Kerkyra | - | Panionios GSS | 0:1 | ||||
| 2. Round | 27/08/2017 | Panionios GSS | - | Apollon Smyrnis | 2:0 |  |
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| 3. Round | 10/09/2017 | Panionios GSS | - | Panetolikos | 1:1 | ||||
| 4. Round | 18/09/2017 | PAS Giannina | - | Panionios GSS | 1:1 | ||||
| 5. Round | 24/09/2017 | Panionios GSS | - | AE Lárissa | 4:1 | ||||
| 7. Round | 14/10/2017 | Panionios GSS | - | Olympiakos Piraeus | 3:4 | ||||
| 8. Round | 22/10/2017 | Asteras Tripolis | - | Panionios GSS | 0:1 | ||||
| 9. Round | 29/10/2017 | Panionios GSS | - | AEK Athen | 0:1 |  |
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| 10. Round | 04/11/2017 | Atromitos | - | Panionios GSS | 0:0 | ||||
| 11. Round | 19/11/2017 | Xanthi FC | - | Panionios GSS | 2:0 | ||||
| 12. Round | 26/11/2017 | Panionios GSS | - | PAOK Saloniki | 2:2 | ||||
| 13. Round | 03/12/2017 | Panathinaikos | - | Panionios GSS | 0:1 | ||||
| 14. Round | 09/12/2017 | Panionios GSS | - | Platanias Chanion | 2:1 | ||||
| 15. Round | 18/12/2017 | Levadiakos | - | Panionios GSS | 2:1 |
Iran