12. Round | 05/11/2021 | FC Twente | - | Heracles Almelo | 1:0 | ||||
13. Round | 20/11/2021 | Heracles Almelo | - | Fortuna Sittard | 3:1 | ||||
14. Round | 28/11/2021 | FC Utrecht | - | Heracles Almelo | 1:0 | ||||
15. Round | 04/12/2021 | Heracles Almelo | - | sc Heerenveen | 0:1 | ||||
16. Round | 12/12/2021 | Vitesse | - | Heracles Almelo | 2:1 | ||||
17. Round | 18/12/2021 | Heracles Almelo | - | FC Groningen | 4:2 | ||||
18. Round | 22/12/2021 | Heracles Almelo | - | SC Cambuur | 1:1 | ||||
20. Round | 23/01/2022 | Heracles Almelo | - | Go Ahead Eagles | 1:1 | ||||
21. Round | 06/02/2022 | AFC Ajax | - | Heracles Almelo | 3:0 | ||||
22. Round | 11/02/2022 | Heracles Almelo | - | FC Utrecht | 1:0 | ||||
23. Round | 19/02/2022 | AZ Alkmaar | - | Heracles Almelo | 2:1 | ||||
24. Round | 26/02/2022 | Heracles Almelo | - | PEC Zwolle | 2:0 | ||||
25. Round | 06/03/2022 | PSV Eindhoven | - | Heracles Almelo | 3:1 | ||||
26. Round | 13/03/2022 | Heracles Almelo | - | Vitesse | 0:0 | ||||
29. Round | 10/04/2022 | Heracles Almelo | - | Feyenoord | 1:4 | ||||
32. Round | 07/05/2022 | Willem II | - | Heracles Almelo | 2:0 |