| 1. Round | 15/08/2021 | Liverpool FC U23 | - | Manchester City U23 | 0:0 | ||||
| 5. Round | 19/09/2021 | Liverpool FC U23 | - | Leeds United U23 | 0:4 |  |
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| 6. Round | 24/09/2021 | Chelsea FC U23 | - | Liverpool FC U23 | 4:3 | ||||
| 7. Round | 02/10/2021 | Manchester United U23 | - | Liverpool FC U23 | 3:0 | ||||
| 8. Round | 16/10/2021 | Liverpool FC U23 | - | Arsenal FC U23 | 3:0 | ||||
| 9. Round | 25/10/2021 | Blackburn Rovers U23 | - | Liverpool FC U23 | 2:2 |  |
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| 10. Round | 30/10/2021 | Liverpool FC U23 | - | Derby County U23 | 3:1 | |
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| 11. Round | 06/11/2021 | West Ham United U23 | - | Liverpool FC U23 | 3:0 | ||||
| 12. Round | 20/11/2021 | Liverpool FC U23 | - | Crystal Palace U23 | 0:3 | ||||
| 13. Round | 28/11/2021 | Liverpool FC U23 | - | Leicester City U23 | 3:0 | ||||
| 17. Round | 15/01/2022 | Liverpool FC U23 | - | Everton FC U23 | 1:1 |
England