5. Round | 31/07/2022 | El Paso Locomotive | - | Louisville City FC | 0:1 | ||||
6. Round | 28/08/2022 | Miami FC | - | Louisville City FC | 1:0 | ||||
7. Round | 04/09/2022 | Louisville City FC | - | Sacramento Republic | 3:1 | ||||
7. Round | 08/09/2022 | FC Tulsa | - | Louisville City FC | 2:2 | ||||
7. Round | 11/09/2022 | Pittsburgh Riverhounds | - | Louisville City FC | 0:0 | ||||
7. Round | 18/09/2022 | Louisville City FC | - | Loudoun United | 4:2 | ||||
8. Round | 02/10/2022 | Rio Grande Valley FC | - | Louisville City FC | 0:1 | ||||
8. Round | 06/10/2022 | Louisville City FC | - | Detroit City FC | 2:1 | ||||
8. Round | 16/10/2022 | Louisville City FC | - | Hartford Athletic | 2:1 |