| 4. Round | 28/08/2021 | F91 Dudelange | - | US Hostert | 2:2 | ||||
| 5. Round | 12/09/2021 | RFCU Luxemburg | - | F91 Dudelange | 3:4 | ||||
| 6. Round | 18/09/2021 | F91 Dudelange | - | Union Titus Pétange | 3:1 | ||||
| 8. Round | 26/09/2021 | F91 Dudelange | - | Etzella Ettelbruck | 6:1 | ||||
| 10. Round | 24/10/2021 | F91 Dudelange | - | Victoria Rosport | 4:1 |  |
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| 13. Round | 28/11/2021 | Swift Hesperange | - | F91 Dudelange | 1:0 | ||||
| 16. Round | 05/02/2022 | F91 Dudelange | - | Progrès Niedercorn | 1:2 | ||||
| 20. Round | 06/03/2022 | Union Titus Pétange | - | F91 Dudelange | 0:1 | ||||
| 22. Round | 20/03/2022 | Etzella Ettelbruck | - | F91 Dudelange | 0:4 | ||||
| 28. Round | 08/05/2022 | FC Rodange 91 | - | F91 Dudelange | 0:2 |  |
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