| 2. Round | 01/08/2020 | Puebla FC | - | Cruz Azul | 1:1 | ||||
| 8. Round | 05/09/2020 | Pumas UNAM | - | Puebla FC | 4:1 |  |
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| 9. Round | 09/09/2020 | Puebla FC | - | CF América | 2:3 | ||||
| 10. Round | 12/09/2020 | FC Juárez | - | Puebla FC | 1:0 | |
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| 11. Round | 19/09/2020 | Club Necaxa | - | Puebla FC | 0:1 | ||||
| 15. Round | 24/10/2020 | Puebla FC | - | Club León | 1:2 | |
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| 16. Round | 31/10/2020 | Atlas Guadalajara | - | Puebla FC | 0:1 | ||||
| 17. Round | 07/11/2020 | Puebla FC | - | Atlético San Luis | 1:0 | |
Uruguay