| 1. Round | 13/01/2025 | CF Monterrey | - | Puebla FC | 1:1 |  |
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| 2. Round | 18/01/2025 | Puebla FC | - | Atlético San Luis | 1:2 | ||||
| 3. Round | 25/01/2025 | Cruz Azul | - | Puebla FC | 1:1 | ||||
| 4. Round | 29/01/2025 | Puebla FC | - | Mazatlán FC | 0:1 | ||||
| 5. Round | 02/02/2025 | Santos Laguna | - | Puebla FC | 0:2 | ||||
| 6. Round | 08/02/2025 | Puebla FC | - | CF América | 1:2 | |
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| 7. Round | 15/02/2025 | Atlas Guadalajara | - | Puebla FC | 3:2 | ||||
| 11. Round | 08/03/2025 | Puebla FC | - | Pumas UNAM | 1:3 | ||||
| 12. Round | 15/03/2025 | Puebla FC | - | Deportivo Toluca | 0:3 | ||||
| 13. Round | 29/03/2025 | FC Juárez | - | Puebla FC | 2:0 | |
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| 14. Round | 05/04/2025 | Puebla FC | - | UANL Tigres | 0:0 | |
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| 15. Round | 13/04/2025 | Club León | - | Puebla FC | 1:0 | |
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| 17. Round | 19/04/2025 | Puebla FC | - | Club Necaxa | 0:1 | |
Uruguay