| 2. Round | 17/01/2021 | Pumas UNAM | - | Mazatlán FC | 3:0 |  |
|||
| 3. Round | 25/01/2021 | Gallos Blancos | - | Pumas UNAM | 2:0 | ||||
| 4. Round | 31/01/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 5. Round | 07/02/2021 | CF Monterrey | - | Pumas UNAM | 1:0 | ||||
| 6. Round | 14/02/2021 | Deportivo Toluca | - | Pumas UNAM | 1:0 | ||||
| 17. Round | 03/05/2021 | Pumas UNAM | - | CF América | 0:1 |
Mexico