1. Round | 14/08/2021 | Fortuna Sittard | - | FC Twente | 2:1 | ||||
3. Round | 27/08/2021 | Fortuna Sittard | - | RKC Waalwijk | 2:2 | ||||
4. Round | 12/09/2021 | Sparta Rotterdam | - | Fortuna Sittard | 3:1 | ||||
5. Round | 18/09/2021 | sc Heerenveen | - | Fortuna Sittard | 1:0 | ||||
6. Round | 21/09/2021 | Fortuna Sittard | - | AFC Ajax | 0:5 | ||||
9. Round | 16/10/2021 | Fortuna Sittard | - | SC Cambuur | 1:0 | ||||
10. Round | 22/10/2021 | Willem II | - | Fortuna Sittard | 1:1 | ||||
11. Round | 31/10/2021 | Go Ahead Eagles | - | Fortuna Sittard | 4:3 | ||||
13. Round | 20/11/2021 | Heracles Almelo | - | Fortuna Sittard | 3:1 | ||||
2. Round | 02/12/2021 | AZ Alkmaar | - | Fortuna Sittard | 2:1 | ||||
15. Round | 05/12/2021 | Feyenoord | - | Fortuna Sittard | 5:0 |