| 1. Round | 22/07/2018 | Atenas | - | Defensor Sporting | 2:5 | ||||
| 4. Round | 12/08/2018 | Defensor Sporting | - | Rampla Juniors | 2:2 | ||||
| 5. Round | 19/08/2018 | Fénix | - | Defensor Sporting | 1:2 | ||||
| 6. Round | 26/08/2018 | Defensor Sporting | - | Nacional | 2:0 | ||||
| 7. Round | 02/09/2018 | Progreso | - | Defensor Sporting | 0:0 | ||||
| 8. Round | 08/09/2018 | CA Cerro | - | Defensor Sporting | 1:1 | ||||
| 12. Round | 14/10/2018 | Liverpool | - | Defensor Sporting | 2:1 |
Uruguay