| 3. Round | 17/07/2022 | Pumas UNAM [U20] | - | Club Necaxa [U20] | 1:2 | ||||
| 4. Round | 22/07/2022 | Club Necaxa [U20] | - | FC Juárez [U20] | 1:2 | ||||
| 7. Round | 07/08/2022 | Atlético San Luis [U20] | - | Club Necaxa [U20] | 2:2 | ||||
| 8. Round | 12/08/2022 | Club Necaxa [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 13. Round | 06/09/2022 | Santos Laguna [U20] | - | Club Necaxa [U20] | 3:2 | ||||
| 14. Round | 10/09/2022 | Club Necaxa [U20] | - | CF América [U20] | 1:2 | ||||
| 17. Round | 01/10/2022 | Atlas Guadalajara [U20] | - | Club Necaxa [U20] | 2:1 |
Mexico