| 1. Round | 07/01/2023 | Deportivo Guadalajara [] | - | CF Monterrey [] | 2:5 | ||||
| 2. Round | 14/01/2023 | UANL Tigres [] | - | Deportivo Guadalajara [] | 4:1 |  |
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| 3. Round | 22/01/2023 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 2:1 | ||||
| 4. Round | 28/01/2023 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 0:1 | |
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| 5. Round | 04/02/2023 | Club Tijuana [] | - | Deportivo Guadalajara [] | 4:2 | ||||
| 6. Round | 11/02/2023 | Deportivo Guadalajara [] | - | Santos Laguna [] | 0:0 | ||||
| 8. Round | 24/02/2023 | Deportivo Guadalajara [] | - | Club León [] | 2:1 | ||||
| 9. Round | 04/03/2023 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 1:1 | ||||
| 10. Round | 11/03/2023 | CF Monterrey [] | - | Deportivo Guadalajara [] | 3:1 | |
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| 11. Round | 19/03/2023 | Deportivo Guadalajara [] | - | Club Tijuana [] | 1:4 | ||||
| 12. Round | 25/03/2023 | Club León [] | - | Deportivo Guadalajara [] | 2:2 | |
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| 13. Round | 01/04/2023 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 2:1 | |
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| 15. Round | 15/04/2023 | Santos Laguna [] | - | Deportivo Guadalajara [] | 5:3 |  |
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| 18. Round | 06/05/2023 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 4:2 | |
Mexico