| 1. Round | 09/04/2022 | Fluminense RJ | - | Santos FC | 0:0 | ||||
| 2. Round | 17/04/2022 | Santos FC | - | Coritiba - PR | 2:1 | ||||
| 4. Round | 03/05/2022 | São Paulo FC | - | Santos FC | 2:1 | ||||
| 5. Round | 08/05/2022 | Santos FC | - | Cuiabá - MT | 4:1 | ||||
| 6. Round | 15/05/2022 | Goiás - GO | - | Santos FC | 1:0 | ||||
| 9. Round | 04/06/2022 | Athletico Paranaense | - | Santos FC | 2:2 | ||||
| 12. Round | 15/06/2022 | Juventude - RS | - | Santos FC | 1:2 | ||||
| 14. Round | 25/06/2022 | Corinthians SP | - | Santos FC | 0:0 | ||||
| 15. Round | 02/07/2022 | Santos FC | - | Flamengo RJ | 1:2 |
Uruguay