| 2. Round | 15/01/2022 | CF Monterrey [U16] | - | Deportivo Guadalajara [U16] | 2:2 | ||||
| 3. Round | 22/01/2022 | Deportivo Guadalajara [U16] | - | Club León [U16] | 2:1 |  |
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| 7. Round | 19/02/2022 | Deportivo Guadalajara [U16] | - | Mazatlán FC [U16] | 7:1 | ||||
| 8. Round | 26/02/2022 | UANL Tigres [U16] | - | Deportivo Guadalajara [U16] | 1:4 | ||||
| 9. Round | 05/03/2022 | Deportivo Guadalajara [U16] | - | Atlas Guadalajara [U16] | 2:3 | |
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| 14. Round | 09/04/2022 | Mazatlán FC [U16] | - | Deportivo Guadalajara [U16] | 1:2 | ||||
| 17. Round | 30/04/2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 3:0 | ||||
| 18. Round | 07/05/2022 | Deportivo Guadalajara [U16] | - | UANL Tigres [U16] | 4:3 |
Mexico