| 5. Round | 12/02/2022 | Inter de Querétaro | - | CD Zap | 0:3 | ||||
| 6. Round | 18/02/2022 | Inter Playa | - | Inter de Querétaro | 3:0 | ||||
| 9. Round | 12/03/2022 | Sporting Canamy | - | Inter de Querétaro | 2:0 | ||||
| 1. Round | 23/03/2022 | Inter de Querétaro | - | Cañoneros FC | 0:1 | ||||
| 11. Round | 27/03/2022 | Lobos ULMX | - | Inter de Querétaro | 0:0 | ||||
| 12. Round | 02/04/2022 | Inter de Querétaro | - | Reboceros de La Piedad | 1:1 |
Mexico