| 1. Round | 09/03/2025 | Charleston Battery | - | Louisville City FC | 1:2 |  |
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| 2. Round | 15/03/2025 | Charleston Battery | - | Rhode Island FC | 2:0 | ||||
| 4. Round | 29/03/2025 | North Carolina FC | - | Charleston Battery | 2:1 | |
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| 5. Round | 05/04/2025 | Charleston Battery | - | Tampa Bay Rowdies | 2:1 | ||||
| 6. Round | 13/04/2025 | Charleston Battery | - | Pittsburgh Riverhounds | 2:1 | ||||
| 7. Round | 20/04/2025 | Indy Eleven | - | Charleston Battery | 1:3 | ||||
| 8. Round | 03/05/2025 | Charleston Battery | - | Hartford Athletic | 4:2 | ||||
| 9. Round | 11/05/2025 | Tampa Bay Rowdies | - | Charleston Battery | 1:3 | ||||
| 10. Round | 18/05/2025 | Charleston Battery | - | San Antonio FC | 4:0 | ||||
| 11. Round | 24/05/2025 | Detroit City FC | - | Charleston Battery | 1:3 |
USA