| 1. Round | 21/07/2018 | Santos Laguna [U15] | - | Club Necaxa [U15] | 3:1 |  |
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| 3. Round | 04/08/2018 | Santos Laguna [U15] | - | UANL Tigres [U15] | 1:1 | ||||
| 4. Round | 11/08/2018 | Club León [U15] | - | Santos Laguna [U15] | 1:0 | ||||
| 5. Round | 18/08/2018 | Santos Laguna [U15] | - | Monarcas Morelia [U15] | 1:1 | ||||
| 7. Round | 01/09/2018 | Santos Laguna [U15] | - | CF Monterrey [U15] | 2:2 | |
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| 2. Round | 18/09/2018 | Deportivo Guadalajara [U15] | - | Santos Laguna [U15] | 1:2 | ||||
| 11. Round | 29/09/2018 | Santos Laguna [U15] | - | Deportivo Guadalajara [U15] | 1:2 | ||||
| 6. Round | 03/10/2018 | Atlas Guadalajara [U15] | - | Santos Laguna [U15] | 6:1 | ||||
| 12. Round | 06/10/2018 | UANL Tigres [U15] | - | Santos Laguna [U15] | 2:0 |  |
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| 13. Round | 13/10/2018 | Santos Laguna [U15] | - | Club León [U15] | 2:3 | ||||
| 15. Round | 27/10/2018 | Santos Laguna [U15] | - | Atlas Guadalajara [U15] | 3:2 |
Mexico