| 2. Round | 31/07/2021 | Club León [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 3. Round | 06/08/2021 | Club Tijuana [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 4. Round | 13/08/2021 | FC Juárez [U20] | - | Club Tijuana [U20] | 1:3 |  |
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| 7. Round | 27/08/2021 | Club Tijuana [U20] | - | CF Monterrey [U20] | 1:0 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 9. Round | 16/09/2021 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 3:0 | ||||
| 12. Round | 03/10/2021 | Club Tijuana [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 14. Round | 20/10/2021 | Club Tijuana [U20] | - | Deportivo Guadalajara [U20] | 1:2 |
Mexico