| 1. Round | 30/04/2022 | Central Español | - | La Luz | 3:2 | ||||
| 2. Round | 06/05/2022 | Atenas | - | Central Español | 1:1 | ||||
| 3. Round | 14/05/2022 | Central Español | - | CA Cerro | 1:2 | ||||
| 4. Round | 21/05/2022 | Sud América | - | Central Español | 2:1 |  |
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| 5. Round | 25/05/2022 | Uruguay Montevideo | - | Central Español | 2:0 | ||||
| 6. Round | 30/05/2022 | Central Español | - | Miramar Misiones | 1:1 | |
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| 7. Round | 04/06/2022 | Villa Española | - | Central Español | 2:1 | |
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| 9. Round | 19/06/2022 | Racing | - | Central Español | 1:0 | |
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| 10. Round | 23/06/2022 | Central Español | - | Rampla Juniors | 2:0 | ||||
| 11. Round | 25/06/2022 | Progreso | - | Central Español | 1:1 |
Uruguay