| 1. Round | 18/08/2021 | F91 Dudelange | - | FC Wiltz 71 | 3:0 | ||||
| 3. Round | 22/08/2021 | Jeunesse Esch | - | F91 Dudelange | 0:3 | ||||
| 4. Round | 28/08/2021 | F91 Dudelange | - | US Hostert | 2:2 | ||||
| 5. Round | 12/09/2021 | RFCU Luxemburg | - | F91 Dudelange | 3:4 | ||||
| 6. Round | 18/09/2021 | F91 Dudelange | - | Union Titus Pétange | 3:1 | ||||
| 7. Round | 22/09/2021 | US Mondorf | - | F91 Dudelange | 0:1 | ||||
| 8. Round | 26/09/2021 | F91 Dudelange | - | Etzella Ettelbruck | 6:1 | ||||
| 9. Round | 17/10/2021 | FC Differdange 03 | - | F91 Dudelange | 3:2 | ||||
| 10. Round | 24/10/2021 | F91 Dudelange | - | Victoria Rosport | 4:1 | ||||
| 11. Round | 06/11/2021 | CS FOLA Esch | - | F91 Dudelange | 0:3 | ||||
| 12. Round | 21/11/2021 | F91 Dudelange | - | UNA Strassen | 1:1 | ||||
| 13. Round | 28/11/2021 | Swift Hesperange | - | F91 Dudelange | 1:0 | ||||
| 14. Round | 04/12/2021 | F91 Dudelange | - | FC Rodange 91 | 5:1 | ||||
| 15. Round | 11/12/2021 | RM Hamm Benfica | - | F91 Dudelange | 0:4 | ||||
| 25. Round | 16/04/2022 | F91 Dudelange | - | CS FOLA Esch | 2:3 |
Luxembourg