| 15. Round | 15/08/2021 | Puerto Montt | - | Deportes Iquique | 0:0 | ||||
| 16. Round | 24/08/2021 | Coquimbo Unido | - | Deportes Iquique | 3:1 | ||||
| 17. Round | 29/08/2021 | Deportes Iquique | - | Fernández Vial | 1:3 | ||||
| 18. Round | 02/09/2021 | San Marcos | - | Deportes Iquique | 4:2 | ||||
| 19. Round | 05/09/2021 | Deportes Iquique | - | Barnechea | 4:2 |  |
|||
| 20. Round | 16/09/2021 | San Luis | - | Deportes Iquique | 1:1 | ||||
| 21. Round | 23/09/2021 | Deportes Iquique | - | Deportes Copiapó | 2:1 | |
|||
| 24. Round | 08/10/2021 | Universidad de Concepción | - | Deportes Iquique | 3:1 | ||||
| 30. Round | 13/11/2021 | Deportes Iquique | - | Puerto Montt | 4:2 |  |
Uruguay