| 1. Round | 17/02/2022 | Deportes Melipilla | - | Universidad de Concepción | 0:2 |  |
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| 2. Round | 23/02/2022 | Rangers | - | Deportes Melipilla | 1:0 | |
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| 3. Round | 02/03/2022 | Deportes Melipilla | - | Puerto Montt | 1:1 | ||||
| 4. Round | 11/03/2022 | Recoleta | - | Deportes Melipilla | 1:2 | ||||
| 5. Round | 16/03/2022 | Deportes Melipilla | - | Deportes Copiapó | 2:1 | ||||
| 8. Round | 09/04/2022 | Deportes Melipilla | - | Cobreloa | 0:0 | ||||
| 9. Round | 18/04/2022 | San Luis | - | Deportes Melipilla | 2:1 | ||||
| 12. Round | 29/04/2022 | Deportes Melipilla | - | Barnechea | 2:1 | ||||
| 13. Round | 08/05/2022 | Fernández Vial | - | Deportes Melipilla | 1:1 | ||||
| 16. Round | 22/05/2022 | Deportes Melipilla | - | Santa Cruz | 1:0 | ||||
| 22. Round | 02/08/2022 | Deportes Copiapó | - | Deportes Melipilla | 2:1 | ||||
| 23. Round | 10/08/2022 | Deportes Melipilla | - | Unión San Felipe | 1:0 |
Uruguay