| 1. Round | 19/09/2021 | Lobos ULMX | - | Sporting Canamy | 0:0 | ||||
| 2. Round | 26/09/2021 | Yalmakan FC | - | Lobos ULMX | 1:0 | ||||
| 3. Round | 01/10/2021 | Inter Playa | - | Lobos ULMX | 3:1 | ||||
| 4. Round | 10/10/2021 | Lobos ULMX | - | Reboceros de La Piedad | 0:1 | ||||
| 5. Round | 13/10/2021 | Deportivo Dongu | - | Lobos ULMX | 2:2 |  |
Mexico