| 1. Round | 18/09/2021 | Lobos Huerta | - | Club Calor | 2:1 |  |
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| 2. Round | 26/09/2021 | Aguacateros CDU | - | Lobos Huerta | 6:1 | ||||
| 3. Round | 03/10/2021 | Lobos Huerta | - | Guerreros Xico | 4:2 |  |
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| 4. Round | 10/10/2021 | Huracanes Izcalli | - | Lobos Huerta | 0:3 | ||||
| 5. Round | 13/10/2021 | Lobos Huerta | - | CD Cuautla | 1:1 | ||||
| 7. Round | 22/10/2021 | Alebrijes de Oaxaca II | - | Lobos Huerta | 4:0 | ||||
| 8. Round | 30/10/2021 | Club Calor | - | Lobos Huerta | 5:0 | ||||
| 9. Round | 06/11/2021 | Lobos Huerta | - | Aguacateros CDU | 0:2 | ||||
| 10. Round | 10/11/2021 | Guerreros Xico | - | Lobos Huerta | 1:4 | |
Mexico