| 2. Round | 22/01/2022 | Leones Negros II | - | Mazorqueros | 0:1 |  |
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| 11. Round | 26/03/2022 | Leones Negros II | - | Saltillo FC | 2:1 |  |
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| 8. Round | 29/03/2022 | Tuzos de la UAZ | - | Leones Negros II | 2:3 | ||||
| 12. Round | 02/04/2022 | Tritones Vallarta | - | Leones Negros II | 1:2 | ||||
| 1. Round | 07/04/2022 | Gavilanes de Matamoros | - | Leones Negros II | 2:2 | ||||
| 13. Round | 10/04/2022 | Leones Negros II | - | Catedráticos Elite | 0:0 |
Mexico