| 1. Round | 23/02/2025 | Houston Dynamo | - | FC Dallas | 1:2 | ||||
| 2. Round | 03/03/2025 | Houston Dynamo | - | Inter Miami CF | 1:4 | ||||
| 3. Round | 08/03/2025 | Columbus Crew | - | Houston Dynamo | 0:0 |  |
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| 4. Round | 16/03/2025 | Houston Dynamo | - | Real Salt Lake | 1:2 | ||||
| 5. Round | 23/03/2025 | Seattle Sounders | - | Houston Dynamo | 0:0 | ||||
| 16. Round | 29/05/2025 | New York City FC | - | Houston Dynamo | 0:3 | |
USA