| 1. Round | 20/09/2020 | Colima FC | - | Gavilanes de Matamoros | 2:0 | ||||
| 3. Round | 03/10/2020 | Alacranes de Durango | - | Gavilanes de Matamoros | 5:0 | ||||
| 4. Round | 10/10/2020 | Gavilanes de Matamoros | - | Cimarrones de Sonora II | 1:0 | ||||
| 6. Round | 23/10/2020 | Gavilanes de Matamoros | - | Leones Negros II | 1:0 | ||||
| 5. Round | 31/10/2020 | Saltillo FC | - | Gavilanes de Matamoros | 0:0 | ||||
| 7. Round | 05/11/2020 | Tecos Fútbol Club | - | Gavilanes de Matamoros | 1:0 | ||||
| 2. Round | 28/11/2020 | Gavilanes de Matamoros | - | Tuzos de la UAZ | 1:0 | ||||
| 10. Round | 06/12/2020 | Gavilanes de Matamoros | - | Atlético San Luis II | 1:0 | ||||
| 11. Round | 13/12/2020 | Reboceros de La Piedad | - | Gavilanes de Matamoros | 0:1 | ||||
| 15. Round | 06/02/2021 | Cimarrones de Sonora II | - | Gavilanes de Matamoros | 0:1 | ||||
| 18. Round | 06/03/2021 | Gavilanes de Matamoros | - | Tecos Fútbol Club | 1:0 | ||||
| 21. Round | 03/04/2021 | Atlético San Luis II | - | Gavilanes de Matamoros | 1:1 |  |
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| 22. Round | 10/04/2021 | Gavilanes de Matamoros | - | Reboceros de La Piedad | 3:0 |
Mexico