4. Round | 10/07/2021 | FC Cincinnati | - | Columbus Crew | 2:2 | ||||
4. Round | 18/07/2021 | Columbus Crew | - | New York City FC | 2:1 | ||||
4. Round | 22/07/2021 | Columbus Crew | - | Nashville SC | 0:0 | ||||
4. Round | 24/07/2021 | Atlanta United FC | - | Columbus Crew | 0:1 | ||||
4. Round | 31/07/2021 | New York City FC | - | Columbus Crew | 4:1 | ||||
5. Round | 05/08/2021 | Columbus Crew | - | D.C. United | 2:4 | ||||
5. Round | 19/08/2021 | New York RB | - | Columbus Crew | 1:0 | ||||
6. Round | 05/09/2021 | Orlando City | - | Columbus Crew | 3:2 | ||||
6. Round | 19/09/2021 | New England Revolution | - | Columbus Crew | 1:1 |