| 3. Round | 07/08/2021 | MFK Zemplín Michalovce | - | AS Trenčín | 1:2 | ||||
| 4. Round | 13/08/2021 | AS Trenčín | - | MFK Ružomberok | 1:1 | ||||
| 6. Round | 28/08/2021 | AS Trenčín | - | ŠKF Sereď | 0:0 | ||||
| 7. Round | 11/09/2021 | MŠK Žilina | - | AS Trenčín | 1:3 | ||||
| 8. Round | 18/09/2021 | AS Trenčín | - | FK Senica | 3:3 |  |
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| 9. Round | 24/09/2021 | FK Pohronie | - | AS Trenčín | 2:2 | |
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| 10. Round | 03/10/2021 | AS Trenčín | - | Spartak Trnava | 0:1 | ||||
| 11. Round | 15/10/2021 | Tatran Liptovský Mikuláš | - | AS Trenčín | 2:1 | ||||
| 12. Round | 23/10/2021 | Zlaté Moravce | - | AS Trenčín | 0:1 | ||||
| 13. Round | 31/10/2021 | AS Trenčín | - | Slovan Bratislava | 2:3 | ||||
| 15. Round | 19/11/2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
| 16. Round | 27/11/2021 | AS Trenčín | - | FC DAC 1904 | 0:1 | ||||
| 18. Round | 11/12/2021 | AS Trenčín | - | MŠK Žilina | 1:3 | ||||
| 19. Round | 18/12/2021 | FK Senica | - | AS Trenčín | 1:0 | ||||
| 20. Round | 12/02/2022 | AS Trenčín | - | FK Pohronie | 3:0 |
Slovakia