| 6. Round | 12/09/2010 | River Plate | - | Arsenal de Sarandí | 1:0 | ||||
| 7. Round | 19/09/2010 | Newell's Old Boys | - | River Plate | 1:0 | ||||
| 8. Round | 27/09/2010 | River Plate | - | Quilmes | 1:1 |  |
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| 9. Round | 04/10/2010 | Banfield | - | River Plate | 2:2 | ||||
| 10. Round | 11/10/2010 | River Plate | - | Gimnasia de La Plata | 0:0 | ||||
| 11. Round | 18/10/2010 | Godoy Cruz | - | River Plate | 2:2 | |
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| 12. Round | 23/10/2010 | River Plate | - | Racing Club | 1:1 | ||||
| 14. Round | 16/11/2010 | River Plate | - | Boca Juniors | 1:0 | ||||
| 15. Round | 21/11/2010 | San Lorenzo | - | River Plate | 0:0 | ||||
| 16. Round | 28/11/2010 | River Plate | - | Olimpo de Bahía Blanca | 1:0 | |
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| 17. Round | 04/12/2010 | Colón de Santa Fe | - | River Plate | 1:2 |  |
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| 18. Round | 08/12/2010 | River Plate | - | Estudiantes | 0:4 | |
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| 19. Round | 13/12/2010 | Lanús | - | River Plate | 1:4 | |
Argentina
Spain 
