| 1. Round | 14/02/2011 | Tigre | - | River Plate | 0:0 | ||||
| 2. Round | 20/02/2011 | River Plate | - | Huracán | 2:0 |  |
|||
| 3. Round | 27/02/2011 | Independiente | - | River Plate | 0:1 | ||||
| 4. Round | 06/03/2011 | River Plate | - | Argentinos Juniors | 0:0 | ||||
| 5. Round | 13/03/2011 | River Plate | - | Vélez Sarsfield | 1:2 | ||||
| 6. Round | 19/03/2011 | Arsenal de Sarandí | - | River Plate | 1:1 | ||||
| 7. Round | 26/03/2011 | River Plate | - | Newell's Old Boys | 2:1 | ||||
| 8. Round | 03/04/2011 | Quilmes | - | River Plate | 0:1 | ||||
| 9. Round | 10/04/2011 | River Plate | - | Banfield | 1:0 | ||||
| 10. Round | 17/04/2011 | Gimnasia de La Plata | - | River Plate | 0:0 | ||||
| 11. Round | 23/04/2011 | River Plate | - | Godoy Cruz | 1:2 | ||||
| 12. Round | 30/04/2011 | Racing Club | - | River Plate | 0:1 | ||||
| 13. Round | 08/05/2011 | River Plate | - | All Boys | 0:2 | ||||
| 14. Round | 15/05/2011 | Boca Juniors | - | River Plate | 2:0 | ||||
| 15. Round | 22/05/2011 | River Plate | - | San Lorenzo | 1:1 |  |
|||
| 16. Round | 30/05/2011 | Olimpo de Bahía Blanca | - | River Plate | 0:0 | ||||
| 17. Round | 06/06/2011 | River Plate | - | Colón de Santa Fe | 1:1 | ||||
| 18. Round | 12/06/2011 | Estudiantes | - | River Plate | 1:1 | |
|||
| 19. Round | 18/06/2011 | River Plate | - | Lanús | 1:2 | |
Argentina
Spain 
