| 2. Round | 15/05/2021 | Charleston Battery | - | Charlotte Independence | 0:3 | ||||
| 2. Round | 23/05/2021 | Charleston Battery | - | New York RB II | 2:2 |  |
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| 3. Round | 19/06/2021 | Charleston Battery | - | Miami FC | 2:1 | ||||
| 3. Round | 24/06/2021 | Charlotte Independence | - | Charleston Battery | 3:0 | ||||
| 3. Round | 27/06/2021 | Charleston Battery | - | Loudoun United | 3:0 | ||||
| 4. Round | 07/07/2021 | Charleston Battery | - | Pittsburgh Riverhounds | 1:1 | ||||
| 5. Round | 14/08/2021 | Charleston Battery | - | Loudoun United | 1:0 | ||||
| 5. Round | 18/08/2021 | Hartford Athletic | - | Charleston Battery | 2:1 |  |
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| 6. Round | 08/09/2021 | Charleston Battery | - | Tampa Bay Rowdies | 0:1 | ||||
| 6. Round | 16/09/2021 | Atlanta United II | - | Charleston Battery | 1:1 | ||||
| 6. Round | 19/09/2021 | Miami FC | - | Charleston Battery | 1:1 | ||||
| 6. Round | 23/09/2021 | Charleston Battery | - | New York RB II | 2:3 | ||||
| 6. Round | 26/09/2021 | Pittsburgh Riverhounds | - | Charleston Battery | 3:3 | ||||
| 7. Round | 03/10/2021 | Charleston Battery | - | Tampa Bay Rowdies | 1:2 | |
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| 7. Round | 08/10/2021 | Tampa Bay Rowdies | - | Charleston Battery | 4:2 |
Sweden