| 1. Round | 20/03/2021 | Club San José | - | Atlético Palmaflor | 1:3 | ||||
| 3. Round | 03/04/2021 | Club San José | - | Royal Pari | 0:3 | ||||
| 4. Round | 12/04/2021 | Real Potosí | - | Club San José | 3:0 |  |
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| 5. Round | 24/04/2021 | Club San José | - | CD Guabirá | 0:1 | ||||
| 6. Round | 04/05/2021 | Blooming | - | Club San José | 4:0 | |
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| 7. Round | 08/05/2021 | Club San José | - | Bolívar | 0:5 |
Bolivia