| 1. Round | 05/08/2005 | Club Brugge KV | - | Excelsior Mouscron | 2:0 | ||||
| 2. Round | 13/08/2005 | Excelsior Mouscron | - | Sporting Lokeren | 0:2 | ||||
| 3. Round | 20/08/2005 | Sporting Charleroi | - | Excelsior Mouscron | 1:0 | ||||
| 4. Round | 27/08/2005 | Excelsior Mouscron | - | KVC Westerlo | 1:0 | ||||
| 5. Round | 10/09/2005 | RSC Anderlecht | - | Excelsior Mouscron | 3:1 | ||||
| 7. Round | 21/09/2005 | SV Zulte Waregem | - | Excelsior Mouscron | 4:1 |  |
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| 8. Round | 24/09/2005 | Excelsior Mouscron | - | RAA La Louviére | 2:1 | |
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| 9. Round | 02/10/2005 | Cercle Brugge | - | Excelsior Mouscron | 1:0 | ||||
| 11. Round | 22/10/2005 | KRC Genk | - | Excelsior Mouscron | 1:0 | ||||
| 13. Round | 05/11/2005 | Excelsior Mouscron | - | FC Brussels | 1:1 | ||||
| 19. Round | 21/01/2006 | Sporting Lokeren | - | Excelsior Mouscron | 1:1 | ||||
| 20. Round | 28/01/2006 | Excelsior Mouscron | - | Sporting Charleroi | 0:1 | ||||
| 21. Round | 04/02/2006 | KVC Westerlo | - | Excelsior Mouscron | 0:5 | |
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| 22. Round | 11/02/2006 | Excelsior Mouscron | - | RSC Anderlecht | 0:1 | ||||
| 32. Round | 22/04/2006 | Lierse SK (old) | - | Excelsior Mouscron | 2:0 |
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