| 2. Round | 03/02/2018 | Royal Pari | - | Club Aurora | 3:0 | ||||
| 4. Round | 18/02/2018 | Royal Pari | - | Nacional Potosí | 1:0 |  |
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| 5. Round | 24/02/2018 | The Strongest | - | Royal Pari | 3:0 | ||||
| 6. Round | 04/03/2018 | Royal Pari | - | Destroyers | 2:2 | |
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| 7. Round | 08/03/2018 | Royal Pari | - | Sport Boys Warnes | 1:2 | ||||
| 8. Round | 13/03/2018 | Royal Pari | - | Blooming | 0:1 | ||||
| 9. Round | 17/03/2018 | Club Aurora | - | Royal Pari | 0:0 | ||||
| 10. Round | 31/03/2018 | Royal Pari | - | Club San José | 0:2 | ||||
| 11. Round | 07/04/2018 | Nacional Potosí | - | Royal Pari | 2:2 | ||||
| 12. Round | 14/04/2018 | Royal Pari | - | The Strongest | 0:2 | ||||
| 13. Round | 23/04/2018 | Destroyers | - | Royal Pari | 0:2 |
Paraguay