| 2. Round | 24/03/2021 | Independiente Juniors | - | Liga de Portoviejo | 3:0 | ||||
| 5. Round | 14/04/2021 | Independiente Juniors | - | Gualaceo SC | 2:0 | ||||
| 6. Round | 23/04/2021 | El Nacional | - | Independiente Juniors | 4:0 | ||||
| 11. Round | 02/06/2021 | Guayaquil SC | - | Independiente Juniors | 1:2 | ||||
| 13. Round | 09/06/2021 | Gualaceo SC | - | Independiente Juniors | 0:0 | ||||
| 15. Round | 16/06/2021 | América de Quito | - | Independiente Juniors | 1:1 | ||||
| 16. Round | 21/06/2021 | Independiente Juniors | - | Atlético Porteño | 3:0 | ||||
| 17. Round | 24/06/2021 | Cumbayá | - | Independiente Juniors | 2:0 | ||||
| 18. Round | 27/06/2021 | Independiente Juniors | - | Chacaritas FC | 3:2 |  |
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| 19. Round | 04/07/2021 | El Nacional | - | Independiente Juniors | 1:0 | ||||
| 20. Round | 09/07/2021 | Independiente Juniors | - | Gualaceo SC | 1:3 | ||||
| 23. Round | 18/07/2021 | Independiente Juniors | - | Liga de Portoviejo | 3:1 |
Ecuador