| 1. Round | 07/01/2023 | Santos Laguna [] | - | Atlético San Luis [] | 5:0 | ||||
| 7. Round | 18/02/2023 | Club Tijuana [] | - | Santos Laguna [] | 2:0 | ||||
| 8. Round | 25/02/2023 | Santos Laguna [] | - | Mazatlán FC [] | 2:0 | ||||
| 9. Round | 04/03/2023 | UANL Tigres [] | - | Santos Laguna [] | 3:3 | ||||
| 10. Round | 11/03/2023 | Santos Laguna [] | - | Atlas Guadalajara [] | 3:0 | ||||
| 12. Round | 25/03/2023 | CF Monterrey [] | - | Santos Laguna [] | 2:1 | ||||
| 14. Round | 08/04/2023 | Mazatlán FC [] | - | Santos Laguna [] | 0:1 | ||||
| 15. Round | 15/04/2023 | Santos Laguna [] | - | Deportivo Guadalajara [] | 5:3 | ||||
| 16. Round | 22/04/2023 | Atlético San Luis [] | - | Santos Laguna [] | 0:1 | ||||
| 17. Round | 29/04/2023 | Club León [] | - | Santos Laguna [] | 3:0 |
Mexico