| 1. Round | 06/02/2016 | Sud América | - | Defensor Sporting | 2:0 | ||||
| 4. Round | 28/02/2016 | Defensor Sporting | - | Danubio | 3:2 |  |
|||
| 5. Round | 06/03/2016 | Rentistas | - | Defensor Sporting | 0:1 | ||||
| 6. Round | 20/03/2016 | Defensor Sporting | - | Liverpool | 1:2 | ||||
| 7. Round | 02/04/2016 | Villa Teresa | - | Defensor Sporting | 2:2 | ||||
| 8. Round | 10/04/2016 | Defensor Sporting | - | Nacional | 2:4 | ||||
| 13. Round | 22/05/2016 | El Tanque Sisley | - | Defensor Sporting | 5:6 |
Paraguay