| 1. Round | 21/08/2021 | RSC Anderlecht [U18] | - | KV Mechelen [U18] | 2:1 | ||||
| 2. Round | 28/08/2021 | Sporting Charleroi [U18] | - | RSC Anderlecht [U18] | 1:4 | ||||
| 6. Round | 25/09/2021 | SV Zulte Waregem [U18] | - | RSC Anderlecht [U18] | 3:4 | ||||
| 7. Round | 02/10/2021 | RSC Anderlecht [U18] | - | Cercle Brugge [U18] | 6:1 | ||||
| 10. Round | 23/10/2021 | Standard Liège [U18] | - | RSC Anderlecht [U18] | 3:1 |  |
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| 14. Round | 27/11/2021 | KV Mechelen [U18] | - | RSC Anderlecht [U18] | 2:0 | ||||
| 8. Round | 01/12/2021 | Royal Antwerp FC [U18] | - | RSC Anderlecht [U18] | 1:2 | ||||
| 18. Round | 05/02/2022 | KAA Gent [U18] | - | RSC Anderlecht [U18] | 0:1 | ||||
| 19. Round | 12/02/2022 | RSC Anderlecht [U18] | - | Royal Antwerp FC [U18] | 1:3 | ||||
| 20. Round | 19/02/2022 | Cercle Brugge [U18] | - | RSC Anderlecht [U18] | 3:7 | ||||
| 13. Round | 26/02/2022 | Sint-Truidense VV [U18] | - | RSC Anderlecht [U18] | 0:1 | ||||
| 21. Round | 05/03/2022 | RSC Anderlecht [U18] | - | KRC Genk [U18] | 2:3 | ||||
| 22. Round | 12/03/2022 | Oud-Heverlee Leuven [U18] | - | RSC Anderlecht [U18] | 1:2 |  |
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| 12. Round | 20/04/2022 | RSC Anderlecht [U18] | - | Club Brugge KV [U18] | 2:2 |
Belgium