| 1. Round | 17/04/2021 | Seattle Sounders | - | Minnesota United FC | 4:0 | ||||
| 1. Round | 24/04/2021 | Los Angeles FC | - | Seattle Sounders | 1:1 |  |
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| 2. Round | 13/05/2021 | San Jose Earthquakes | - | Seattle Sounders | 0:1 | ||||
| 4. Round | 05/07/2021 | Colorado Rapids | - | Seattle Sounders | 1:1 | ||||
| 4. Round | 18/07/2021 | Minnesota United FC | - | Seattle Sounders | 1:0 | ||||
| 4. Round | 23/07/2021 | Austin FC | - | Seattle Sounders | 0:1 | ||||
| 4. Round | 26/07/2021 | Seattle Sounders | - | Sporting Kansas City | 1:3 |
USA