| 3. Round | 10/04/2022 | Sporting Kansas City | - | Nashville SC | 1:2 | ||||
| 4. Round | 08/05/2022 | Nashville SC | - | Real Salt Lake | 2:0 | ||||
| 4. Round | 15/05/2022 | Houston Dynamo | - | Nashville SC | 2:0 |  |
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| 4. Round | 19/05/2022 | Nashville SC | - | CF Montréal | 2:1 | ||||
| 4. Round | 22/05/2022 | Nashville SC | - | Atlanta United FC | 2:2 | |
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| 5. Round | 25/06/2022 | D.C. United | - | Nashville SC | 1:3 | ||||
| 6. Round | 24/07/2022 | FC Cincinnati | - | Nashville SC | 1:1 | ||||
| 7. Round | 07/08/2022 | Nashville SC | - | Toronto FC | 3:4 | ||||
| 7. Round | 15/08/2022 | Nashville SC | - | Minnesota United FC | 1:2 | ||||
| 7. Round | 28/08/2022 | Vancouver Whitecaps | - | Nashville SC | 0:3 | ||||
| 7. Round | 01/09/2022 | Nashville SC | - | Colorado Rapids | 4:1 |
USA