| 3. Round | 08/08/2020 | Deportivo Guadalajara [U20] | - | Puebla FC [U20] | 0:0 | ||||
| 9. Round | 08/09/2020 | Deportivo Guadalajara [U20] | - | Gallos Blancos [U20] | 3:1 | ||||
| 10. Round | 11/09/2020 | Club Necaxa [U20] | - | Deportivo Guadalajara [U20] | 1:1 | ||||
| 12. Round | 26/09/2020 | Deportivo Guadalajara [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 13. Round | 04/10/2020 | Club Tijuana [U20] | - | Deportivo Guadalajara [U20] | 0:3 | ||||
| 4. Round | 07/10/2020 | FC Juárez [U20] | - | Deportivo Guadalajara [U20] | 2:1 |  |
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| 1. Round | 11/10/2020 | Deportivo Guadalajara [U20] | - | Club León [U20] | 3:1 | ||||
| 14. Round | 17/10/2020 | Deportivo Guadalajara [U20] | - | Atlas Guadalajara [U20] | 2:3 | ||||
| 15. Round | 25/10/2020 | Deportivo Guadalajara [U20] | - | Cruz Azul [U20] | 1:1 | ||||
| 16. Round | 31/10/2020 | Pumas UNAM [U20] | - | Deportivo Guadalajara [U20] | 2:1 | ||||
| 17. Round | 07/11/2020 | Deportivo Guadalajara [U20] | - | CF Monterrey [U20] | 1:2 | ||||
| 2. Round | 13/11/2020 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 2:2 |
Mexico