| 1. Round | 14/08/1981 | MVV | - | FC Twente | 3:1 | ||||
| 2. Round | 18/08/1981 | FC Twente | - | PEC Zwolle | 2:0 | ||||
| 3. Round | 21/08/1981 | De Graafschap | - | FC Twente | 1:6 |  |
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| 4. Round | 25/08/1981 | FC Twente | - | AFC Ajax | 2:1 | ||||
| 5. Round | 28/08/1981 | FC Den Haag | - | FC Twente | 3:2 | ||||
| 6. Round | 11/09/1981 | FC Twente | - | FC Groningen | 1:1 | ||||
| 8. Round | 25/09/1981 | FC Twente | - | NAC Breda | 0:1 | ||||
| 9. Round | 03/10/1981 | PSV Eindhoven | - | FC Twente | 4:0 | ||||
| 12. Round | 06/11/1981 | FC Twente | - | Roda JC Kerkrade | 1:3 | ||||
| 13. Round | 10/11/1981 | AZ '67 Alkmaar | - | FC Twente | 2:1 | ||||
| 14. Round | 21/11/1981 | FC Twente | - | SBV Haarlem | 0:2 | ||||
| 15. Round | 28/11/1981 | NEC Nijmegen | - | FC Twente | 2:1 | ||||
| 16. Round | 23/01/1982 | Willem II | - | FC Twente | 0:2 | ||||
| 19. Round | 29/01/1982 | PEC Zwolle | - | FC Twente | 5:1 | ||||
| 18. Round | 06/02/1982 | FC Twente | - | MVV | 2:2 | ||||
| 17. Round | 23/02/1982 | FC Twente | - | Feyenoord | 4:0 | ||||
| 33. Round | 02/04/1982 | FC Twente | - | Willem II | 2:0 | ||||
| 27. Round | 09/04/1982 | Go Ahead Eagles | - | FC Twente | 0:0 |
Netherlands