| 1. Round | 13/09/2020 | FC Emmen | - | VVV-Venlo | 3:5 | ||||
| 2. Round | 18/09/2020 | VVV-Venlo | - | FC Utrecht | 1:1 | ||||
| 3. Round | 26/09/2020 | sc Heerenveen | - | VVV-Venlo | 1:0 | ||||
| 4. Round | 03/10/2020 | VVV-Venlo | - | ADO Den Haag | 1:2 |  |
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| 5. Round | 17/10/2020 | AZ Alkmaar | - | VVV-Venlo | 2:2 |  |
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| 6. Round | 24/10/2020 | VVV-Venlo | - | AFC Ajax | 0:13 | ||||
| 7. Round | 31/10/2020 | FC Groningen | - | VVV-Venlo | 2:1 | ||||
| 8. Round | 07/11/2020 | VVV-Venlo | - | Heracles Almelo | 3:2 | ||||
| 9. Round | 21/11/2020 | Willem II | - | VVV-Venlo | 2:1 | ||||
| 10. Round | 28/11/2020 | VVV-Venlo | - | PEC Zwolle | 2:2 | ||||
| 11. Round | 05/12/2020 | RKC Waalwijk | - | VVV-Venlo | 3:2 | ||||
| 12. Round | 13/12/2020 | VVV-Venlo | - | Feyenoord | 0:3 | ||||
| 13. Round | 19/12/2020 | VVV-Venlo | - | FC Twente | 1:2 | |
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| 14. Round | 22/12/2020 | PSV Eindhoven | - | VVV-Venlo | 4:1 | ||||
| 18. Round | 24/01/2021 | FC Twente | - | VVV-Venlo | 0:1 | ||||
| 19. Round | 27/01/2021 | VVV-Venlo | - | Vitesse | 4:1 |
Netherlands