| 1. Round | 20/07/2021 | Irtysh Omsk | - | Zenit Izhevsk | 2:1 | ||||
| 2. Round | 23/07/2021 | Dinamo Barnaul | - | Zenit Izhevsk | 3:1 | ||||
| 4. Round | 07/08/2021 | Lada Tolyatti | - | Zenit Izhevsk | 2:1 | ||||
| 5. Round | 15/08/2021 | FK Chelyabinsk | - | Zenit Izhevsk | 1:0 | ||||
| 6. Round | 21/08/2021 | Zenit Izhevsk | - | FK Ural 2 | 1:3 | ||||
| 7. Round | 29/08/2021 | Zenit Izhevsk | - | FK Amkar Perm | 0:1 | ||||
| 8. Round | 05/09/2021 | Nosta Novotroitsk | - | Zenit Izhevsk | 1:0 | ||||
| 9. Round | 12/09/2021 | Zenit Izhevsk | - | FK Novosibirsk | 0:1 | ||||
| 16. Round | 23/10/2021 | Zenit Izhevsk | - | FK Orenburg 2 | 1:1 | ||||
| 17. Round | 31/10/2021 | Spartak Tuymazy | - | Zenit Izhevsk | 4:0 | ||||
| 18. Round | 04/11/2021 | Volga Ulyanovsk | - | Zenit Izhevsk | 0:1 | ||||
| 19. Round | 09/11/2021 | Torpedo Miass | - | Zenit Izhevsk | 1:2 | ||||
| 20. Round | 14/11/2021 | FK Tyumen | - | Zenit Izhevsk | 3:0 | ||||
| 22. Round | 09/04/2022 | FK Novosibirsk | - | Zenit Izhevsk | 2:0 | ||||
| 23. Round | 17/04/2022 | Zenit Izhevsk | - | Nosta Novotroitsk | 4:1 | ||||
| 24. Round | 24/04/2022 | FK Amkar Perm | - | Zenit Izhevsk | 2:1 | ||||
| 25. Round | 30/04/2022 | FK Ural 2 | - | Zenit Izhevsk | 2:0 |
Russia