| 11. Round | 17/10/2020 | FK Krasnodar | - | Rubin Kazan | 3:1 | ||||
| 12. Round | 24/10/2020 | FK Krasnodar | - | Spartak Moskva | 1:3 | ||||
| 13. Round | 31/10/2020 | Akhmat Grozny | - | FK Krasnodar | 2:0 | ||||
| 14. Round | 08/11/2020 | Zenit St. Petersburg | - | FK Krasnodar | 3:1 | ||||
| 15. Round | 21/11/2020 | FK Krasnodar | - | FK Tambov | 1:0 | ||||
| 16. Round | 28/11/2020 | FK Khimki | - | FK Krasnodar | 1:0 | ||||
| 17. Round | 05/12/2020 | FK Krasnodar | - | Rotor Volgograd | 5:0 | ||||
| 18. Round | 13/12/2020 | FK Krasnodar | - | Lokomotiv Moskva | 5:0 | ||||
| 19. Round | 17/12/2020 | FK Krasnodar | - | FK Ufa | 1:0 | ||||
| 20. Round | 28/02/2021 | FK Krasnodar | - | FK Ural | 2:2 | ||||
| 21. Round | 07/03/2021 | Spartak Moskva | - | FK Krasnodar | 6:1 | ||||
| 22. Round | 14/03/2021 | FK Tambov | - | FK Krasnodar | 0:4 | ||||
| 23. Round | 18/03/2021 | FK Krasnodar | - | Dinamo Moskva | 2:3 | ||||
| 24. Round | 03/04/2021 | FK Krasnodar | - | Akhmat Grozny | 0:5 | ||||
| 25. Round | 11/04/2021 | Arsenal Tula | - | FK Krasnodar | 1:0 | ||||
| 26. Round | 17/04/2021 | FK Krasnodar | - | Zenit St. Petersburg | 2:2 |  |
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| 29. Round | 08/05/2021 | CSKA Moskva | - | FK Krasnodar | 3:1 | ||||
| 30. Round | 16/05/2021 | FK Rostov | - | FK Krasnodar | 1:3 | |
Russia