| 3. Round | 18/07/2022 | UANL Tigres | - | Club Tijuana | 1:0 | ||||
| 16. Round | 26/08/2022 | Club Tijuana | - | Santos Laguna | 0:2 | ||||
| 11. Round | 29/08/2022 | Club Tijuana | - | CF Monterrey | 0:3 | ||||
| 12. Round | 02/09/2022 | Atlético San Luis | - | Club Tijuana | 0:0 | ||||
| 13. Round | 08/09/2022 | Club Tijuana | - | Deportivo Guadalajara | 1:2 | ||||
| 15. Round | 19/09/2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 17. Round | 03/10/2022 | Club León | - | Club Tijuana | 2:2 |
Colombia