| 1. Round | 05/02/2022 | Fénix | - | Peñarol | 1:0 | ||||
| 2. Round | 11/02/2022 | Montevideo City Torque | - | Fénix | 1:2 |  |
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| 3. Round | 20/02/2022 | Fénix | - | Montevideo Wanderers | 0:3 |  |
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| 4. Round | 25/02/2022 | Plaza Colonia | - | Fénix | 1:1 | |
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| 5. Round | 12/03/2022 | Fénix | - | Boston River | 0:2 | ||||
| 6. Round | 20/03/2022 | River Plate | - | Fénix | 3:1 | ||||
| 7. Round | 03/04/2022 | Fénix | - | Cerro Largo | 2:0 | |
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| 8. Round | 10/04/2022 | Fénix | - | Cerrito | 2:0 | |
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| 9. Round | 16/04/2022 | Defensor Sporting | - | Fénix | 2:1 | ||||
| 10. Round | 24/04/2022 | Fénix | - | Albion | 2:1 | |
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| 12. Round | 15/05/2022 | Fénix | - | Danubio | 0:0 | ||||
| 13. Round | 21/05/2022 | Deportivo Maldonado | - | Fénix | 0:1 | ||||
| 14. Round | 30/05/2022 | Fénix | - | Rentistas | 2:1 | ||||
| 15. Round | 05/06/2022 | Liverpool | - | Fénix | 1:0 |
Uruguay
Italy