| 3. Round | 18/02/2012 | Guaraní | - | Club Nacional | 1:3 |  |
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| 4. Round | 25/02/2012 | Libertad | - | Guaraní | 2:2 | ||||
| 5. Round | 02/03/2012 | Guaraní | - | Tacuary | 4:0 | |
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| 6. Round | 10/03/2012 | Guaraní | - | Sportivo Luqueño | 3:1 | |
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| 7. Round | 18/03/2012 | Sol de América | - | Guaraní | 0:1 | ||||
| 8. Round | 24/03/2012 | Guaraní | - | Club Olimpia | 0:1 | ||||
| 9. Round | 01/04/2012 | Cerro Porteño | - | Guaraní | 1:0 | ||||
| 10. Round | 08/04/2012 | Guaraní | - | Sportivo Carapeguá | 2:1 | ||||
| 11. Round | 14/04/2012 | Cerro de Franco | - | Guaraní | 2:1 | ||||
| 12. Round | 18/04/2012 | Independiente CG | - | Guaraní | 0:1 | ||||
| 14. Round | 28/04/2012 | Club Nacional | - | Guaraní | 1:1 | ||||
| 15. Round | 05/05/2012 | Guaraní | - | Libertad | 2:3 | ||||
| 16. Round | 13/05/2012 | Tacuary | - | Guaraní | 1:1 | ||||
| 17. Round | 12/06/2012 | Sportivo Luqueño | - | Guaraní | 2:2 | ||||
| 19. Round | 27/06/2012 | Club Olimpia | - | Guaraní | 2:0 | |
Paraguay