| 1. Round | 25/07/2021 | Metalist 1925 Kharkiv | - | Rukh Lviv | 2:1 | ||||
| 2. Round | 01/08/2021 | Vorskla Poltava | - | Rukh Lviv | 2:0 | ||||
| 12. Round | 24/10/2021 | Rukh Lviv | - | FC Mynai | 2:2 |  |
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| 13. Round | 31/10/2021 | Rukh Lviv | - | FK Oleksandriya | 0:0 |  |
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| 14. Round | 06/11/2021 | Chernomorets Odessa | - | Rukh Lviv | 4:3 | ||||
| 15. Round | 20/11/2021 | Shakhtar Donetsk | - | Rukh Lviv | 2:0 | |
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| 16. Round | 28/11/2021 | Rukh Lviv | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 17. Round | 04/12/2021 | Rukh Lviv | - | Vorskla Poltava | 0:0 | |
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| 18. Round | 11/12/2021 | NK Veres | - | Rukh Lviv | 1:1 |
Argentina